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CAS RN: 3056-17-5 | Product Number: D3580

2',3'-Didehydro-3'-deoxythymidine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • d4T
  • 2',3'-Anhydrothymidine
  • 1-(2,3-Dideoxy-β-D-glycero-2-pentenofuranosyl)thymine
  • Stavudine
  • Sanilvudine
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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number D3580
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__2N__2O__4 = 224.22  
Physical State (20 deg.C) Solid
CAS RN 3056-17-5
Reaxys Registry Number 618327
PubChem Substance ID 87559878
SDBS (AIST Spectral DB) 52178
MDL Number

MFCD00132921

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D -44.0 to -48.0 deg(C=0.69, H2O)
Properties (reference)
Melting Point 166 °C(dec.)
Specific Rotation -46° (C=0.69,H2O)
Solubility in water Soluble
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H373 : May cause damage to organs through prolonged or repeated exposure.
H341 : Suspected of causing genetic defects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# XP2075000
Transport Information:
HS Number 2934.99.4400
Application
Stavudine: A Nucleoside Reverse Transcriptase Inhibitor

Stavudine is a nucleoside reverse transcriptase inhibitor that active against HIV1. Stavudine is a synthetic nucleoside analogue of the naturally occurring nucleoside thymidine. Intracellularly, stavudine is converted by cellular enzymes to the active metabolite, stavudine-5'-triphosphate. The triphosphate inhibits the activity of viral reverse transcriptase both by competing with the natural substrate, thymidine-5'-triphosphate, and by its incorporation into viral DNA causing termination of viral DNA chain. (The product is for research purpose only.)

References


Application
Synthesis and Anti-HIV-1 Activities of Novel Podophyllotoxin Derivatives Containing Stavudine

References


PubMed Literature


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