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CAS RN: 69123-98-4 | Product Number: D4200

Fialuridine


Purity: >98.0%(HPLC)
Synonyms:
  • 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil
  • FIAU
  • 2'-Fluoro-5-iodoarauracil
Documents:
10MG
$172.00
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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number D4200
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__9H__1__0FIN__2O__5 = 372.09 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 69123-98-4
Reaxys Registry Number 892318
PubChem Substance ID 160871154
Merck Index (14) 4069
MDL Number

MFCD00866922

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Properties (reference)
Melting Point 226 °C
GHS
Related Laws:
RTECS# YQ9512500
Transport Information:
HS Number 2940.00.6000
Application
Fialuridine (FIAU): A Thymidine Nucleoside Analog with Activity against Herpes Viruses and Hepatitis B Virus (HBV)

Fialuridine (FIAU) is a thymidine nucleoside analog with activity against various herpes viruses and hepatitis B virus (HBV). FIAU blocks the action of DNA polymerases, thus inhibiting viral replication. FIAU owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. On the other hand, it appear that FIAU causes mitochondrial toxicity leading to fatal liver failure alongside lactic acidosis. (The product is for research purpose only.)

References


PubMed Literature


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