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CAS RN: 50924-49-7 | Product Number: M2399
Mizoribine
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Purity: >98.0%(HPLC)
Synonyms:
- 1-(β-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|---|
| 50MG |
$180.00
|
1 | 1 | 8 |
|
|
| 250MG |
$623.00
|
1 | Ships from Philadelphia the same day* | 7 |
|
* Items in stock locally typically ship the same day of ordering. Items from Japan stock are able to ship from a US warehouse within 2 weeks after ordering. For additional estimated shipment times, please refer to the Shipping Simulation tool. Note: Excludes regulated items and items that ship on ice.
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*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | M2399 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__3N__3O__6 = 259.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 50924-49-7 |
| Reaxys Registry Number | 8155135 |
| PubChem Substance ID | 253659680 |
| Merck Index (14) | 6222 |
| MDL Number | MFCD00057221 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -25.0 to -27.0 deg(C=2,H2O) |
Properties (reference)
| Melting Point | 198 °C(dec.) |
| Specific Rotation | -26° (C=2,H2O) |
| Maximum Absorption Wavelength | 280 nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H340 : May cause genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P302 + P352 : IF ON SKIN: Wash with plenty of soap and water. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P362 : Take off contaminated clothing and wash before reuse. P405 : Store locked up. |
Related Laws:
| RTECS# | NI3980000 |
Transport Information:
| HS Number | 2934.99.9001 |
Application
Mizoribine: An Imidazole Nucleoside Immunosuppressive and Antiviral Agent
Mizoribine (bredinin, MZR), an imidazole nucleoside, is an immunosuppressive and an antiviral agent. The immunosuppressive effect of mizoribine has been reported to be due to the inhibition of de novo guanosine synthesis, via inhibition of inosine-5'-monophosphate dehydrogenase (IMPDH).1-4) On the other hand, the combination of mizoribine and interferon (IFN)-α have been reported to show antiviral activities. The mechanisms of action would appear that mizoribine inhibits virus RNA replication based on the depletion of the intracellular pool of guanosine nucleotides by IMPDH inhibition.5-7) In addition, mizoribine has been reported to its anti-coronavirus activity.８) (The product is for research purpose only.)
References
- 1)Studies on bredinin. I. Isolation, characterization, and biological properties
- 2)Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine
- 3)Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism
- 4)Mizoribine and mycophenolate mofetil (a review)
- 5)Antiviral activities of mizoribine and other inosine monophosphate dehydrogenase inhibitors against several ortho-and paramyxoviruses
- 6)Mizoribine inhibits hepatitis C virus RNA replication: Effect of combination with interferon-α
- 7)Inhibition of bovine viral diarrhea virus (BVDV) by mizoribine: synergistic effect of combination with interferon-α
- 8)Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)-associated coronavirus
PubMed Literature
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