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CAS RN: 13860-38-3 | Product Number: M3387

1-Methylpseudouridine


Purity: >99.0%(HPLC)
Synonyms:
  • 1-Methyl-5-β-D-ribofuranosyluracil
  • 1-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione
  • (1S)-1,4-Anhydro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol
  • m1ψ
Documents:
100MG
$258.00
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1G
$1,107.00
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Product Number M3387
Purity / Analysis Method >99.0%(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__4N__2O__6 = 258.23 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
Packaging and Container 100MG-Glass Bottle with Plastic Insert (View image),  1G-Glass Bottle with Plastic Insert (View image)
CAS RN 13860-38-3
Reaxys Registry Number 551569
MDL Number

MFCD10687017

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 99.0 area%
Purity(qNMR) min. 98.0 %
Melting point 187.0 to 191.0 °C
Specific rotation -6.0 to -8.0 deg (C=1, water)
NMR confirm to structure
Properties (reference)
Melting Point 189 °C
GHS
Related Laws:
Transport Information:
HS Number 2934.99.9001
Application
1-Methylpseudouridine (m1Ψ): A Non-Natural Pyrimidine Nucleoside Found in mRNA Vaccines

In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development1). Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses. In protein biosynthesis, 1-methylpseudouridine (m1Ψ) and pseudouridine (Ψ) [P2939 (synthetic)] [P2396] are read like uridine (U) and enable comparatively high protein yields. Furthermore, m1Ψ enhances immune evasion, protein production, and consequently vaccine efficacy.2-4)

References


PubMed Literature

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