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CAS RN: 284461-73-0 | Product Number: O0599

Sorafenib


Purity: >98.0%(T)(HPLC)
Synonyms:
  • BAY 43-9006
  • 4-[4-[3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido]phenoxy]-N-methylpicolinamide
Documents:
500MG
$262.00
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Product Number O0599
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__1H__1__6ClF__3N__4O__3 = 464.83 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 284461-73-0
Reaxys Registry Number 9666200
MDL Number

MFCD06411450

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Volumetric Analysis) min. 98.0 %
Melting point 203.0 to 207.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 205 °C
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H360 : May damage fertility or the unborn child.
H362 : May cause harm to breast-fed children.
H372 : Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P263 : Avoid contact during pregnancy/ while nursing.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.
P270 : Do not eat, drink or smoke when using this product.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# US4588870
Transport Information:
HS Number 2933.39.9200
Application
Sorafenib: An Inhibitor of Multiple Protein Kinases

The Ras/Raf/MEK/ERK signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. Sorafenib (BAY 43-9006) inhibits intracellular Raf kinases (C-Raf, B-Raf and mutant B-Raf) and cell surface receptor tyrosine kinases (c-KIT, FLT- 3, RET, VEGFR-1, VEGFR- 2, VEGFR- 3, and PDGFR).1-4) Several of these kinases are thought to be involved in tumor cell signaling, angiogenesis and apoptosis. In fact, sorafenib decreases tumor cell proliferation and angiogenesis in vitro. There are reports, that sorafenib also inhibits LRRK2 (Leucine-rich repeat kinase 2) –G2019S that is a promising therapeutic target for the treatment of Parkinson's disease.5) (The product is for research purpose only.)

References


Documents (Note: Some products will not have analytical charts available.)
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