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CAS RN: 39809-25-1 | Product Number: P2164

Penciclovir


Purity: >98.0%(T)(HPLC)
Synonyms:
  • BRL 39123
  • 2-Amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one
  • 9-[4-Hydroxy-3-(hydroxymethyl)butyl]guanine
Documents:
200MG
$186.00
6   Contact Us 20  

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Product Number P2164
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__5N__5O__3 = 253.26 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Condition to Avoid Heat Sensitive
Packaging and Container 200MG-Glass Bottle with Plastic Insert (View image)
CAS RN 39809-25-1
Reaxys Registry Number 4501039
PubChem Substance ID 253662013
Merck Index (14) 7083
MDL Number

MFCD15142866

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Properties (reference)
Melting Point 278 °C
Maximum Absorption Wavelength 253(H2O) nm
Degree of solubility in water 1.7 g/l   20 °C
GHS
Related Laws:
RTECS# UP0789400
Transport Information:
HS Number 2933.99.7500
Application
Penciclovir: An Antiherpesvirus Agent

Penciclovir, an acyclic guanine nucleoside analog, is an antiherpesvirus agent like acyclovir [A1915] . Famciclovir [F0842] is a prodrug of penciclovir. Penciclovir is active against most species in the herpesvirus family. It depends on the activity of the viral enzyme thymidine kinase (TK) to convert the agent to a monophosphate form and subsequently interfere with viral DNA replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to penciclovir, which has extremely low toxicity for human cell. The spectrum of activity of penciclovir against human herpesviruses is similar to that of acyclovir, both compounds having good activity against herpes simplex viruses types 1 and 2 (HSV-1, HSV-2), varicella-zoster virus (VZV), and Epstein-Barr virus (EBV). Like acyclovir, penciclovir has slight activity against cytomegalovirus (CMV).

References


PubMed Literature


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