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CAS RN: 70-00-8 | Product Number: T2511

Trifluorothymidine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • α,α,α-Trifluorothymidine
  • Trifluridine
  • 2'-Deoxy-5-trifluoromethyluridine
Documents:
100MG
$211.00
1   2   21  
1G
$624.00
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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number T2511
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__1F__3N__2O__5 = 296.20 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic
CAS RN 70-00-8
Reaxys Registry Number 568095
PubChem Substance ID 87560183
Merck Index (14) 9687
MDL Number

MFCD00006534

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D +47.0 to +53.0 deg(C=1, H2O)
Properties (reference)
Melting Point 189 °C
Specific Rotation 50° (C=1,H2O)
Solubility in water Soluble
GHS
Related Laws:
RTECS# XP2087500
Transport Information:
HS Number 2934.99.4400
Application
CRISPR Genome Editing / Research on regenerative medicine

Reference


Application
Trifluridine: A Fluorinated Pyrimidine Nucleoside with Anti-Herpesvirus and Antitumor Activities

Trifluridine (trifluorothymidine, TFT), a fluorinated pyrimidine nucleoside, is an anti-herpesvirus agent and an antitumor antimetabolite agent. Thymidylate kinase (TK) is a key enzyme in the synthesis of thymidine-5'-monophosphate [T0845, di-Na salt], an essential precursor for DNA biosynthesis. Trifluridine is incorporated into (virus or tumor) DNA as its triphosphate via phosphorylation by thymidylate kinase (TK), ultimately suppressing DNA replication and inhibiting cell proliferation.1-4) Trifluridine has activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and vaccinia virus.1-3) Recently, a combined antitumor agent TAS-102 (trifluridine with tipiracil, a thymidine phosphorylase inhibitor) has been used in clinical. Inclusion of tipiracil increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. 4-6) (The product is for research purpose only.)

References


PubMed Literature


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