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CAS RN: 58-14-0 | Product Number: P2037
Pyrimethamine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 1G |
¥250.00
|
1 | 5 | ≥100 |
| 5G |
¥440.00
|
2 | 1 | 38 |
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| Product Number | P2037 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__1__3ClN__4 = 248.71 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 58-14-0 |
| Reaxys Registry Number | 219864 |
| PubChem Substance ID | 253660065 |
| Merck Index (14) | 7985 |
| MDL Number | MFCD00057350 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 239.0 to 243.0 °C |
Properties (reference)
| Melting Point | 241 °C |
| Maximum Absorption Wavelength | 276 nm |
| Solubility in water | Insoluble |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. H411 : Toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UV8140000 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| Customs Control Conditions (Q) |
Application
Pyrimethamine, an inhibitor of dihydrofolate reductase
Pyrimethamine is known as an antagonist of folic acid and has an anti-malarial effect. It inhibits dihydrofolate reductase of bacteria and protozoa and affects cell division by inhibiting the conversion of dihydrofolic acid to tetrahydrofolic acid. Its inhibitory effect against human’s dihydrofolate reductase is only 1/1000 in comparison to that of bacteria or protozoa, so that it is considered to be less effective for human. (The product is for research purpose only.)
Related product
Sulfadiazine (S0579)
Related product
Sulfadiazine (S0579)
References
- A 2 : 4-Diamino Pyrimidine in the Treatment of Proguanil-resistant Laboratory Malarial Strains
- Toxoplasmosis (a review)
- Antimalarial compounds: from bench to bedside (a review)
- Effectiveness of Antimalarial Drugs (a review)
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