Anti-GM₂ Monoclonal Antibody

References

• Generation of two murine monoclonal antibodies that can discriminate N-glycolyl and N-acetyl neuraminic acid residues of GM₂ gangliosides
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• The abnormal occurrence and the differentiation-dependent distribution of N-acetyl and N-glycolyl species of the ganglioside GM2 in human germ cell tumors. A study with specific monoclonal antibodies
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• Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells
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• Neuronal accumulation of α- and β-synucleins in the brain of a GM2 gangliosidosis mouse model
  • K. Suzuki, E. Iseki, O. Katsuse, A. Yamaguchi, K. Katsuyama, I. Aoki, S. Yamanaka, K. Kosaka, Neuroreport 2003, 14, 551.
• β-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration
  • S. Kyrkanides, J. H. Miller, S. M. Brouxhon, J. A. Olschowka, H. J. Federoff, Brain Res. Mol. Brain Res. 2005, 133, 286 [Mol. Brain Res.(Incorporated into Brain Res.) 2005, 133, 286].
• The trigeminal retrograde transfer pathway in the treatment of neurodegeneration
  • S. Kyrkanides, M. Yang, R. H. Tallents, J. H. Miller, S. M. Brouxhon, J. A. Olschowka, J. Neuroimmunol. 2009, 209, 139.
• Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation
  • S. Kyrkanides, S. M. Brouxhon, R. H. Tallents, J. H. Miller, J. A. Olschowka, M. K. O'Banion,
    J. Neuroinflammation 2012, 9, 186.