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CAS RN: 3690-10-6 | Product Number: Z0022
Zebularine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 4-Deoxyuridine
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 200MG |
$183.00
|
2 | 1 | 4 |
|
| 1G |
$542.00
|
2 | 1 | ≥60 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | Z0022 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__5 = 228.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 3690-10-6 |
| Reaxys Registry Number | 751056 |
| PubChem Substance ID | 253660306 |
| MDL Number | MFCD04973699 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +156 ～ +166 deg(C=1, MeOH) |
Properties (reference)
| Melting Point | 158 °C(dec.) |
| Specific Rotation | 158° (C=1,MeOH) |
GHS
Related Laws:
| RTECS# | UW7539720 |
Transport Information:
| HS Number | 2934.99.9001 |
Application
Zebularine: An Effective Inhibitor of DNA Methylation
The main epigenetic modification is DNA methylation, and patterns of aberrant DNA methylation are now recognized to be a common hallmark of tumor cells. Zebularine, which is structurally 4-deamino cytidine, is a recently discovered mechanism-based inhibitor of DNA methylation. It is an effective inhibitor of cytidine deaminase and DNA cytosine methyltransferase.
References
- Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases
- Inhibition of DNA methylation and reactivation of silenced genes by zebularine
- Preferential response of cancer cells to zebularine
- Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
- Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression
- The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells
PubMed Literature
Documents
Product Articles
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Specifications
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