Welcome to TCI Website! Reliable Quality Chemical Supplier!
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 69304-47-8 | Product Number: B3404
(E)-5-(2-Bromovinyl)-2'-deoxyuridine
×
![]()
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- Brivudine
- BVdU
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 100MG |
¥1,090.00
|
9 | 1 | 20 |
* For order or inquiry, please contact
Our Authorized Distributors.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
* To send your quote request for bulk quantities, please click on the "Request Bulk Quote" button. Please note that we cannot offer bulk quantities for some products.
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | B3404 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__3BrN__2O__5 = 333.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 69304-47-8 |
| Reaxys Registry Number | 758153 |
| PubChem Substance ID | 87561214 |
| Merck Index (14) | 1378 |
| MDL Number | MFCD00058585 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Specific rotation [a]20/D | +8.0 to +10.0 deg(C=1, MeOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 166 °C(dec.) |
| Specific Rotation | 9° (C=1,MeOH) |
GHS
Related Laws:
| RTECS# | YU7355000 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Brivudine (BVdU): A Nucleoside Analogue Anti-Herpesvirus Agent
Brivudine (BVdU) is a nucleoside analogue anti-herpesvirus agent, and is often used for treatment of herpes simplex virus-1 (HSV-1) and varicella-zoster virus (VZV) infections. Brivudine blocks the action of DNA polymerases, thus inhibiting viral replication. Brivudine owes its effect to preferential phosphorylation by virus-encoded thymidine kinase to its 5'-diphosphate form. After further conversion to triphosphate form, it acts as an inhibitor or alternate substrate for the viral DNA polymerase. Brivudine is also characterized by a well described fatal drug interaction with antitumor agents such as 5-fluorouracil (5-FU) [F0151] and its prodrugs. This is caused by the main metabolite, bromovinyluracil (BVU), irreversibly inhibiting the enzyme dihydropyrimidine dehydrogenase (DPD) which is necessary for inactivating 5-FU. (The product is for research purpose only.)
References
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent
- On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine
- Discovery and development of BVDU (brivudine) as a therapeutic for the treatment of herpes zoster (a review)
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) (a review)
PubMed Literature
Documents
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.