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CAS RN: 202409-33-4 | Product Number: E1492
Etoricoxib
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Purity: >95.0%(T)(HPLC)
Synonyms:
- 5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
- 5-Chloro-3-[4-(methylsulfonyl)phenyl]-2-(2-methyl-5-pyridinyl)pyridine
Product Documents:
| Size | Unit Price | Shanghai | Tianjin | Japan* |
|---|---|---|---|---|
| 200MG |
¥110.00
|
4 | Contact Us | 5 |
| 1G |
¥330.00
|
5 | Contact Us | 12 |
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| Product Number | E1492 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__5ClN__2O__2S = 358.84 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 202409-33-4 |
| Reaxys Registry Number | 8073797 |
| MDL Number | MFCD06797512 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Melting point | 133.0 to 137.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 135 °C |
GHS
Related Laws:
| RTECS# | DW1762210 |
Transport Information:
| Customs Control Conditions (Q) |
Application
Etoricoxib: A Selective Cyclooxygenase-2 (COX-2) Inhibitor
Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID), and a selective inhibitor of COX-2 (cyclooxygenase 2) with a higher COX-1 to COX-2 selectivity ratio than the other COX-2-selective inhibitors, such as rofecoxib [R0206], valdecoxib [V0133] or celecoxib [C2816]. The mechanism of action is mainly by inhibition of the enzyme COX in the arachidonic acid metabolism pathway, resulting in reduced prostaglandin synthesis. In theory, a drug that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1. (The product is for research purpose only.)
References
- Etoricoxib (a review)
- Selective COX-2 inhibitors: a review of their structure-activity relationships (a review)
- RP-HPLC method for simultaneous estimation of Paracetamol and Etoricoxib from bulk and tablets
- Determination of etoricoxib in human plasma by liquid chromatography-tandem mass spectrometry with electrospray ionisation
Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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