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CAS RN: 7770-78-7 | Product Number: A3117
(-)-Arctigenin
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Purity: >95.0%(GC)
Synonyms:
- (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
Product Documents:
| Size | Unit Price | Hyderabad | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
₹4,600.00
|
1 | 18 |
|
| 50MG |
₹10,400.00
|
Contact Us | ≥60 |
|
*Upon orders receipt, Hyderabad stocks will be dispatched on the same day.
*Items available in Japan warehouse will be dispatched in 10-12 working days.
*INR price is exclusive of domestic taxes applicable.
*TCI frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
| Product Number | A3117 |
Purity / Analysis Method 
|
>95.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__4O__6 = 372.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
10MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 7770-78-7 |
| Reaxys Registry Number | 4206071 |
| PubChem Substance ID | 354335432 |
| MDL Number | MFCD00870597 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| Melting point | 98.0 to 102.0 °C |
| Specific rotation [a]20/D | -40.0 to -44.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 100 °C |
| Specific Rotation | -42° (C=1,MeOH) |
| Maximum Absorption Wavelength | 280 nm (EtOH) |
GHS
Related Laws:
| RTECS# | LY9247000 |
Transport Information:
Application
Arctigenin: A Lignin with Wide Pharmacological Actions
Arctigenin and its glycoside, arctiin [A3118], are lignans found in many plants of Arctium lappa L. (AL, family Asteraceae)1). Arctigenin reportedly has wide pharmacological actions, such as antitumor2,3), anti-inflammatory4-6), and antiviral7,8), and anti-Alzheimer9) actions. (The product is for research purpose only.)
References
- 1)Isolation and identification of arctiin and arctigenin in leaves of burdock (Arctium lappa L.) by polyamide column chromatography in combination with HPLC-ESI/MS
- 2)Identification of Arctigenin as an Antitumor Agent Having the Ability to Eliminate the Tolerance of Cancer Cells to Nutrient Starvation
- 3)Arctigenin blocks the unfolded protein response and shows therapeutic antitumor activity
- 4)In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway
- 5)Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway
- 6)Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages
- 7)(-)-Arctigenin as a Lead Structure for Inhibitors of Human Immunodeficiency Virus Type-1 Integrase
- 8)Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus
- 9)Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance
PubMed Literature
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