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CAS RN: 1445-07-4 | Product Number: P2396

Pseudouridine


Purity: >98.0%(HPLC)
Synonyms:
  • 5-(β-D-Ribofuranosyl)uracil
  • 5-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
  • (1S)-1,4-Anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol
Documents:
50MG
$393.00
4   1   21  

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Product Number P2396
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__9H__1__2N__2O__6 = 244.20 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Condition to Avoid Heat Sensitive
Packaging and Container 50MG-Glass Bottle with Plastic Insert (View image)
CAS RN 1445-07-4
Reaxys Registry Number 621385
PubChem Substance ID 354334120
MDL Number

MFCD00038458

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 10.90 to 12.00 %
NMR confirm to structure
Properties (reference)
Melting Point 231 °C(dec.)
Maximum Absorption Wavelength 264(MeOH) nm
GHS
Related Laws:
Transport Information:
HS Number 2934.99.9001
Application
Pseudouridine: The Most Common Modified Nucleoside in RNA

Pseudouridine (5-ribosyluracil, abbreviated by the Greek letter psi- Ψ), the most common modified nucleoside in RNA, is the C-glycoside isomer of the ribonucleoside uridine [U0020]. Pseudouridine is biosynthesized from uridine via the action of pseudouridine synthases in vivo. Nowadays, pseudouridine is identified as a fifth nucleoside in RNA. Pseudouridine is found in lots of tRNAs and rRNAs but never in mRNA. However, recently it has been reported that artificial pseudouridylation dramatically affects mRNA function. The function of pseudouridine is currently not clear, but it is assumed that pseudouridine plays a role in association with RNA stability and/or helping aminoacyl transferases interact with tRNAs.

References


PubMed Literature

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