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CAS RN: 1445-07-4 | Product Number: P2396
Pseudouridine
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Purity: >98.0%(HPLC)
Synonyms:
- 5-(β-D-Ribofuranosyl)uracil
- 5-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione
- (1S)-1,4-Anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 50MG |
$393.00
|
3 | 1 | 21 |
|
* Items in stock locally ship in 1-2 business days. Items from Japan stock are able to ship from a US warehouse within 2 weeks. Please contact TCI for lead times on items not in stock. Excludes regulated items and items that ship on ice.
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| Product Number | P2396 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__6 = 244.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container | 50MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1445-07-4 |
| Reaxys Registry Number | 621385 |
| PubChem Substance ID | 354334120 |
| MDL Number | MFCD00038458 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 10.90 to 12.00 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 231 °C(dec.) |
| Maximum Absorption Wavelength | 264(MeOH) nm |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
Pseudouridine: The Most Common Modified Nucleoside in RNA
Pseudouridine (5-ribosyluracil, abbreviated by the Greek letter psi- Ψ), the most common modified nucleoside in RNA, is the C-glycoside isomer of the ribonucleoside uridine [U0020]. Pseudouridine is biosynthesized from uridine via the action of pseudouridine synthases in vivo. Nowadays, pseudouridine is identified as a fifth nucleoside in RNA. Pseudouridine is found in lots of tRNAs and rRNAs but never in mRNA. However, recently it has been reported that artificial pseudouridylation dramatically affects mRNA function. The function of pseudouridine is currently not clear, but it is assumed that pseudouridine plays a role in association with RNA stability and/or helping aminoacyl transferases interact with tRNAs.
References
- Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs
- Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA
- Pseudouridine in RNA: what, where, how, and why (a review)
- Ribosomal RNA pseudouridines and pseudouridine synthases (a review)
- Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
- Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
PubMed Literature
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Product Documents (Note: Some products will not have analytical charts available.)
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Specifications
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Other Documents
Related Products
Pseudouridine (Synthetic)
| Product # | P2939 |
| CAS RN | 1445-07-4 |
| Purity / Analysis Method: | >98.0%(HPLC)(qNMR) |