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CAS RN: 1445-07-4 | Product Number: P2939
Pseudouridine (Synthetic)
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Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- 5-(β-D-Ribofuranosyl)uracil (Synthetic)
- 5-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione (Synthetic)
- (1S)-1,4-Anhydro-1-(2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)-D-ribitol (Synthetic)
- ψ (Synthetic)
Product Documents:
| Size | Unit Price | Philadelphia, PA | Portland, OR | Japan* | Quantity |
|---|---|---|---|---|---|
| 100MG |
$181.00
|
1 | 1 | 27 |
|
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| Product Number | P2939 |
Purity / Analysis Method 
|
>98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__9H__1__2N__2O__6 = 244.20 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1445-07-4 |
| Reaxys Registry Number | 621385 |
| MDL Number | MFCD00038458 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 231 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2934.99.9001 |
Application
Pseudouridine (Ψ): A Modified Pyrimidine Nucleoside Found in RNA
In recent years, numerous studies have demonstrated the outstanding abilities of mRNA to elicit potent immune, making it a viable new platform for vaccine development.1) Additionally there are reports on incorporation of modified nucleobases into mRNA offering advantages for the generation of potent and long-lived antibody responses.2) In protein biosynthesis, pseudouridines, such as pseudouridine (Ψ) [P2939 (synthetic)] [P2396] and 1-methylpseudouridine (m1Ψ) [M3387], are read like uridine (U) and enable comparatively high protein yields.3) Furthermore, pseudouridine has attracted attention for its function in epitranscriptomics, namely the study of RNA modifications.2,4)
References
- 1) The tangled history of mRNA vaccines (a review)
- 2) Chemical Modifications to RNA: A New Layer of Gene Expression Regulation (a review)
- 3) Messenger RNA modifications: Form, distribution, and function (a review)
- 4) Epitranscriptome sequencing technologies: decoding RNA modifications
PubMed Literature
Please visit the Pubchem page at this link.
Documents
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Specifications
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Other Documents
Related Products
Pseudouridine
| Product # | P2396 |
| CAS RN | 1445-07-4 |
| Purity / Analysis Method: | >98.0%(HPLC) |