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Published TCIMAIL newest issue No.198
Maximum quantity allowed is 999
Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry.1) Coronaviruses cause respiratory tract infections in humans, with most severe cases triggered by SARS, MERS, and, recently, COVID-19 (while the disease is named COVID-19, the virus that causes it was named SARS-CoV-2).2) The lungs are the organs most affected by COVID-19 because the virus (using a special surface glycoprotein) accesses host cells via the enzyme ACE2, which is most abundant in the type II alveolar cells of the lungs.3) Some of the trends in anti-SARS-CoV-2 agent development include the search for the viral proteases 3CLpro or PLpro inhibitors, viral protein expression inhibitors, viral entry to host cells inhibitors, as well as inhibitors of viral replication.4) TCI offers many antiviral agents useful for research and experiment. Currently reported mechanisms and target virus types are summarized below. Literature information is also provided on the "Application" tab in the product details page viewable from the link of Product Number.
Product Name | Target Virus Types | Product No. |
---|---|---|
Mechanisms: Preventing viral RNA release into the host cell nucleus | ||
Amantadine | Influenza A virus | A2318 |
Amantadine Hydrochloride | Influenza A virus | A0588 |
Rimantadine Hydrochloride | Influenza A virus | R0070 |
Mechanisms: RNA synthesis inhibition | ||
Favipiravir | Influenza virus, RNA viruses | F1296 (unavailable in the U.S.) |
Mizoribine | Herpesvirus | M2399 |
PSI-6206 | Chronic hepatitis C virus (HCV) | D4823 |
T-1105 | Influenza virus, RNA viruses | H1485 |
Theaflavin | RNA viruses | T3962 |
Mechanisms: DNA synthesis inhibition | ||
Acyclovir | Herpesvirus (HSV-1, HSV-2) | A1915 |
Brivudine (= BVdU) | Herpesvirus (HSV-1) | B3404 |
Cytarabine (= ara-C) | Herpesvirus | C2035 |
Famciclovir | Herpesvirus, Chronic hepatitis B virus (HBV) | F0842 |
Fialuridine (= FIAU) | Chronic hepatitis B virus (HBV) | D4200 |
Ganciclovir Hydrate | Human cytomegalovirus | G0315 |
Idoxuridine (= IDU) | Herpesvirus | I0258 |
Mizoribine | Herpesvirus | M2399 |
Penciclovir | Herpesvirus | P2164 |
Trifluorothymidine | Herpesvirus | T2511 |
Vidarabine Monohydrate (= ara-A) | DNA virus | V0098 |
Valacyclovir Hydrochloride | Herpesvirus (HSV-1, HSV-2) | V0111 |
Valganciclovir Hydrochloride | Human cytomegalovirus | V0158 |
Mechanisms: Reverse transcriptase inhibition | ||
Abacavir | Human immunodeficiency virus (HIV) | A2694 |
Adefovir Dipivoxil | Chronic hepatitis B virus (HBV) | A2414 |
Azidothymidine (= AZT) | Human immunodeficiency virus (HIV) | A2052 |
2',3'-Dideoxyadenosine (= ddA) | Human immunodeficiency virus (HIV) | D3065 |
Didanosine (= ddI) | Human immunodeficiency virus (HIV) | D3066 |
Entecavir Monohydrate | Chronic hepatitis B virus (HBV) | E0899 |
Efavirenz | Human immunodeficiency virus (HIV) | E0997 |
Emtricitabine | Human immunodeficiency virus (HIV), Chronic hepatitis B virus (HBV) | E1007 |
Lamivudine (= 3TC) | Human immunodeficiency virus (HIV), Chronic hepatitis B virus (HBV) | L0217 |
Nevirapine | Human immunodeficiency virus (HIV) | N0922 |
Stavudine (= d4T) | Human immunodeficiency virus (HIV) | D3580 |
Tenofovir | Human immunodeficiency virus (HIV), Chronic hepatitis B virus (HBV) | T3006 |
Mechanisms: Protease inhibition | ||
Clemizole Hydrochloride | Chronic hepatitis C virus (HCV) | C3468 |
Nelfinavir Mesylate Hydrate | Human immunodeficiency virus (HIV) | N0986 |
Ritonavir | Human immunodeficiency virus (HIV) | R0116 |
Mechanisms: Neuraminidase inhibition | ||
Zanamivir Hydrate | Influenza virus | Z0023 |
Mechanisms: HIV-1 entry inhibition | ||
NBD-556 | Human immunodeficiency virus (HIV) | N1090 |
Mechanisms: Interfering with the conversion of chemicals to energy | ||
Tizoxanide | Various virus | T3862 |
Mechanisms: Immunostimulation | ||
Imiquimod | Herpesvirus, Various virus | I0747 |
Inosine | Herpesvirus | I0037 |
Inosine Pranobex | Herpesvirus, Human immunodeficiency virus (HIV) | I1037 |
Plerixafor | Immunodeficiency virus | P2678 |
Resiquimod | Herpesvirus, Various virus | R0197 |
Mechanisms: Interferon induction | ||
Tilorone Dihydrochloride | Various virus | T2836 |
Mechanisms: Others | ||
Arbidol Hydrochloride | Influenza virus, Chronic hepatitis C virus (HCV), RNA virus | A3402 |
1-Docosanol | Herpesvirus | D0964 |
Moroxydine Hydrochloride | Influenza virus, Various virus | M2443 |
Moronic Acid | Herpesvirus, Human immunodeficiency virus (HIV), Epstein-Barr virus (EBV) | M2610 |
Nitazoxanide | Influenza virus, Chronic hepatitis B virus (HBV), Chronic hepatitis C virus (HCV), Various virus | N1031 |
Pirodavir | Picornavirus | P2665 |
Ribavirin | Various virus | R0077 |