HPMC Capsule Reagents | TCI (Shanghai) Development Co., Ltd.

TCI offers hydroxypropyl methylcellulose (HPMC) encapsulated reagents.^1,2) Our product line includes capsules for amide formation reactions (condensation reactions), Suzuki coupling reactions, which are frequently used in synthetic organic chemistry and drug discovery research, and for photoredox reactions, which have recently received a lot of attention.

Using these encapsulated reagents, you can conduct reactions immediately by adding the capsules to the solution of the starting material without weighing the reaction reagents. Additionally, a reaction-accelerating effect is expected due to the construction of a reaction field in water by HPMC.³⁾ Our encapsulated reagents can accelerate your experiments and library construction in both experimental operations and reactions. Furthermore, since the exact required amount for the reaction is enclosed, it prevents leftover reagents in the laboratory, thereby reducing waste.

Size comparison between HPMC encapsulated reagent and palm

Our practical experimental procedures using these capsules are available on product detail pages for your reference.

Products

Capsule Reagents Encapsulating Multiple Components

R0273: Reagents for Metallophotoredox Cross-Coupling Reactions [NiBr₂(dme), [Ir[dF(CF₃)ppy]₂(dtbbpy)]PF₆, DABCO] (HPMC encapsulated)
R0274: Reagents for Condensation Reactions (EDCI·HCl, HOBt·H₂O) (HPMC encapsulated)
R0275: Reagents for Suzuki-Miyaura Cross-Coupling Reactions [Pd(dppf)Cl₂·CH₂Cl₂, Cs₂CO₃] (HPMC encapsulated)

Capsule Reagents Encapsulating a Condensing Agent

R0273: Reagents for Metallophotoredox Cross-Coupling Reactions [NiBr₂(dme), [Ir[dF(CF₃)ppy]₂(dtbbpy)]PF₆, DABCO] (HPMC encapsulated)
R0274: Reagents for Condensation Reactions (EDCI·HCl, HOBt·H₂O) (HPMC encapsulated)
R0275: Reagents for Suzuki-Miyaura Cross-Coupling Reactions [Pd(dppf)Cl₂·CH₂Cl₂, Cs₂CO₃] (HPMC encapsulated)
R0294: Reagents for Condensation Reactions (DMT-MM) (HPMC encapsulated)
R0295: Reagents for Condensation Reactions (HATU) (HPMC encapsulated)
R0296: Reagents for Condensation Reactions (1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate) (HPMC encapsulated)
R0297: Reagents for Condensation Reactions (HOTU) (HPMC encapsulated)

Capsule Reagents Encapsulating a Palladium Complex, a Copper Salt, a NHC Precursor, a Phosphine Ligand or a Nitrogen Donor Ligand

R0303: Pd(OAc)₂ (HPMC encapsulated)
R0304: Pd(PPh₃)₄ (HPMC encapsulated)
R0305: Pd₂(dba)₃ (HPMC encapsulated)
R0306: PdCl₂(amphos)₂ (HPMC encapsulated)
R0307: PdCl₂(dppf)·CH₂Cl₂ (HPMC encapsulated)
R0308: PdCl₂(PPh₃)₂ (HPMC encapsulated)
R0321: 1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) Dichloride (HPMC encapsulated)
R0312: Cu(OAc)₂ (HPMC encapsulated)
R0314: CuI (HPMC encapsulated)
R0315: CuTC (HPMC encapsulated)
R0316: 1,3-Bis(2,6-diisopropylphenyl)imidazolium Chloride (HPMC encapsulated)
R0300: Xantphos (HPMC encapsulated)
R0301: DPEphos (HPMC encapsulated)
R0302: Xphos (HPMC encapsulated)
R0318: P(tBu)₃·HBF₄ (HPMC encapsulated)
R0319: Tri(o-tolyl)phosphine (HPMC encapsulated)
R0309: 1,10-Phenanthroline (HPMC encapsulated)
R0310: 2,2'-Bipyridyl (HPMC encapsulated)
R0311: 8-Quinolinol (HPMC encapsulated)
R0313: L-Proline (HPMC encapsulated)
R0320: 4,4'-Di-tert-butyl-2,2'-bipyridyl (HPMC encapsulated)

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Advantages

Capsule has an outer diameter of 5 mm and a length of 14 mm and contains a preweighed amount of catalyst or reagent.
Capsules dissolve in the reaction solution, therefore adding capsules makes it simple to carry out reactions.
Dissolves in water, DMSO, DMF, NMP, DMAc, THF/water and dioxane/water. ¹⁾

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